Penicillin is prescribed for treating various bacterial infections. They are the top choices because theyre safer, inexpensive, and they work well on strep bacteria. 10% of the population reports a penicillin allergy but <1% of the whole population is truly allergic. Not all bacterial infections are treated with penicillin, but if you have an infection that is usually treated by penicillin, you may be able to take a drug that is similar to penicillin called a cephalosporin. Up to 10 percent of people report being allergic to penicillin, according to the Centers for Disease Control and Prevention (CDC). Signs and symptoms of penicillin allergy vary from mild skin rashes to severe anaphylactic shock. First, the patient undergoes a series of skin prick tests using gradually increasing amounts of penicillin. Drugs belonging to the sulfonamide class are chemically unrelated to sulfates. Intradermal skin testing is the second part of the evaluation and involves injecting the skin. Is penicillin allergy genetic? Penicillins belong to a class of drug called beta lactams because they contain a special beta lactam ring in their structure that is considered to be responsible for its anti microbial activity. The actual skin testing itself is performed most commonly on either the forearm or back. Using other drugscalled broad-spectrum antibioticsinstead of penicillin can be more expensive and less effective. Having a true allergy to penicillin is serious. Can I take doxycycline if I am allergic to penicillin? 4. It's also very likely that you have outgrown an allergy to penicillin, especially if the reaction happened more than 10 years ago. Ciprofloxacin can cause serious side effects, including tendon problems, damage to your nerves (which may be permanent), serious mood or behavior changes (after just one dose), or low blood sugar (which can lead to coma). If you don't have a reaction to the oral challenge or the skin testing, there is almost a 100 percent chance you are not allergic. An oral dose of penicillin or amoxicillin may also be given to confirm that it is safe to use this antibiotic. The allergist / immunologist will then consider skin testing using several different dilutions of penicillin. However, there are other medications you may be able to take. Most hospitals or clinics have access to an allergist / immunologist who can help facilitate this. vancomycin) are all unrelated to penicillins and are safe to use in the penicillin allergic patient. National Library of Medicines list However, recent studies reveal most people who believe theyre allergic to penicillin may actually be able to safely use it either because they never were truly allergic or because they lost sensitivity over time. What is a true penicillin allergy? There are a number of cephalosporin medications available, including cephalexin (brand name: Keflex), cefaclor (brand name: Ceclor), cefuroxime (brand name: Ceftin), cefadroxil (brand name: Duricef), cefprozil (brand name: Cefzil), ceftibuten (brand name: Cedax), cefdinir (brand name: Omnicef), cefpodoxime, and cefixime (brand name: Suprax). Sometimes, penicillin allergies are over reported because they are confused with side effects of the drug. Some people may experience swelling or pain at the site of the vaccination, fatigue, or muscle or joint pain. We use cookies for various purposes including analytics and personalized marketing. This includes the more than 15 chemically related drugs such as ampicillin, amoxicillin, amoxicillin-clavulanate and methicillin. By giving amoxicillin to patients with a history of reported mild reactions to penicillin, Dr. Jerschow demonstrated that 97% of patients could safely receive penicillin again. Acyclovir is also used to prevent recurrent genital herpes infections. Amoxicillin, for example, is one of the most common oral penicillins. Listen to expert Kimberly G. Blumenthal, MD, MSc, FAAAAI, discuss the complicated reasons why penicillin allergies are over-reported and the many ways in which this can be addressed. However, if youve been told you have a penicillin allergy by a doctor who is not an allergist, you may want to confirm the diagnosis. If certain medications make your skin bloom with hives, cause light-headedness, nausea, difficulty breathing or stomach cramps, or make your throat or mouth swell, it could be the result of a drug allergy. Itching, skin rash, or . An allergic reaction to penicillin in childhood does not automatically predict a reaction as an adult. Examples of sulfonamides includes sulfadiazine, sulfamethizole (brand name: Thiosulfil Forte), sulfamethoxazole (Gantanol), sulfasalazine (Azulfidine), sulfisoxazole (Gantrisin), and various high-strength combinations of three sulfonamides. Using a broad-spectrum antibiotic for an infection like strep throat (which responds quickly to penicillin) also increases the risk of developing a serious antibiotic-related condition. Experiencing an allergic reaction to a sulfonamide antibiotic does not mean that you will react poorly to sulfonamide nonantibiotic drugs. Begin by trying to establish if the harm was caused by medication, or something else. Solensky R. Penicillin allergy: Immediate reactions. Antibiotic allergies are an immunologically mediated response to a pharmaceutical in a sensitized person and are mediated by IgE, IgG, or T lymphocytes. This will allow you to be treated safely with a large penicillin dose. Drug rash with eosinophilia and systemic syndrome (DRESS). 6. information submitted for this request. Can I drink alcohol while taking sulfamethoxazole / trimethoprim DS tablets? The Pfizer and AstraZeneca COVID-19 vaccines do not contain penicillin or any other antibiotics. 2017;17(3):251-5. Brand names for amoxicillin include Amoxil and Moxatag. These conditions include: You may experience side effects of penicillin as happens with other medications that are not an allergic reaction to the drug. 6,8 Patients with anaphylaxis or other severe reactions to penicillin may require further evaluation prior to the use of cephalosporins. In general, it is not recommended that patients who have a history of penicillin allergy carry an epinephrine autoinjector. In cases of a positive penicillin test, either the skin prick or intradermal test will produce a red, raised bump, signifying the presence of an allergy to the medication. Then youll need to schedule a visit with the allergist and get tested for a drug allergy. https://www.merckmanuals.com/professional/infectious-diseases/bacteria-and-antibacterial-drugs/penicillins?query=penicillin%20allergic. skin infection due to Staphylococcus aureus bacteria. It is one of the most frequently used classes of antibiotics in the world. However, molecular traces of these proteins may be present in fish oil, and there is a chance you could have an allergic reaction to fish oil if you are allergic to shellfish. By eating a few cloves of garlic each day, you can effectively fight off all sorts of bacteria, viruses and infections. Save my name, email, and website in this browser for the next time I comment. Amoxicillin belongs to a class of drugs called penicillins. This type of reaction usually happens within an hour after you take penicillin. Eliminating sulfur-rich foods from your diet may help reduce the odor of your burps.Vegetables high in sulfur include: Symptoms include flushing, fast heartbeat, wheezing, hives, dizziness, stomach upset and diarrhoea, collapse, tingling or difficulty swallowing. These types of penicillin are used to treat an extensive variety of infections such as infection of the skin, mouth, ear, respiratory tract, urinary tract, and even sexually transmitted infections like gonorrhea. Most people lose their penicillin allergy over time, even patients with a history of severe reaction such as anaphylaxis. vancomycin) are all unrelated to penicillins and are safe to use in the penicillin allergic patient. It is generally recommended that you avoid all drugs in the immediate penicillin family (amoxicillin, ampicillin, amoxicillin-clavulanate, dicloxacillin, nafcillin, piperacillin-tazobactam as well as certain drugs in the cephalosporin class (a closely related class to penicillins). Systemic reactions such as hives can occur, but are very rare and allergist / immunologists are prepared to treat such reactions. In particular, this supplement is used for osteoarthritis, according to Medline Plus. Required fields are marked *. https://acaai.org/allergies/allergic-conditions/drug-allergies/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783707/, https://www.aaaai.org/Allergist-Resources/Ask-the-Expert/Answers/Old-Ask-the-Experts/acetazolamide. Tests and case studies for medical students. What if I Cant Afford My Allergy Medications? This leads to misdiagnosis and use of inappropriate antibiotics for treating patients condition that are less effective. 2019; doi:10.1001/jama.2018.19283. Swelling of the lips, face or eyes. This type of desensitization wears off, but it can be followed by allergy shots from an allergist that will give you long-lasting protection. Sulfa is synonymous with sulpha, oral sulfonamide antibiotic, and oral sulphonamide antibiotic. Some glucosamine sulfate supplements are made from the shells of crabs, lobster or shrimp -- therefore, you may wish to avoid consuming shellfish-based glucosamine sulfate if you have a shellfish allergy. Serendipity in drug discovery implies the finding of one thing while looking for something else. Keflex is a cephalosporin antibiotic and amoxicillin is a penicillin-type antibiotic. Penicillins. So, in order to establish the diagnosis of penicillin allergy, skin allergy test should be done on patients who complain of allergy to penicillin. Acad Pediatr. J&J says two trial participants had severe allergic reactions after getting Covid vaccine. While penicillin still remains the most widely used antibiotic in the world, Dr. Barbara Baxter, a doctor in Dallas, notes that there is a percentage of the population that must steer clear of this drug. Clindamycin will not work for colds, flu, or other virus infections. Signs and symptoms of penicillin allergy often occur within an hour after taking the drug. How do you get rid of penicillin allergy? These are not allergic reactions. From a regulatory perspective, the TGA has reviewed all the available evidence and determined that the AstraZeneca vaccine can be safely administered 4-12 weeks apart. If you are experiencing serious medical symptoms, please see the Sulfonamides, or sulfa drugs, are a group of medicines used to treat bacterial infections. You may not be able to take this medication again if youve ever had a serious allergic reaction to it. The penicillin family of antibiotics contains over 15 chemically related drugs (e.g. Over 95 percent of people with penicillin allergy can safely take cephalosporins, which are a bit structurally different from penicillins. Dont limit your treatment options find out for sure whether youre allergic. This skin testing is similar to penicillin skin testing. As listed above, there are no food products or antibiotics in the Johnson & Johnson COVID-19 vaccine. What drugs should be avoided with a sulfa allergy? Penicillins belong to a class of antibacterial drugs called beta-lactam antibiotics. American College of Allergy, Asthma & Immunology. Penicillin medications include: Amoxicillin Ampicillin Dicloxacillin Penicillin G Penicillin V Nafcillin Piperacillin Oxacillin Ticarcillin 2018; doi:10.1016/j.mayocp.2017.09.020. Before taking this medication, tell your doctor if you are allergic to any drugs (especially penicillin). Which Is More Stable Thiophene Or Pyridine? However, it is important that you are trained by your healthcare provider on how to administer epinephrine. Its also worth noting that only 20 per cent of people who think they are allergic to penicillin, actually are. But penicillin inhibits the formation of cell wall in bacteria that makes them vulnerable to bodys harsh environment. Symptoms of allergy often appear within few hours of drug intake. Taking it again could be fatal. Can I take Augmentin if Im allergic to penicillin? This largely depends on your history and an allergist / immunologist can help clear this up. Among all groups of antibiotics, penicillins are the oldest and the safest ones with fewer side effects. Severe reactions include anaphylaxis, a life-threatening condition that affects multiple body systems. Here are the groups of protein synthesis inhibitors: Fluoroquinolones are a separate group of drugs with a very wide spectrum of antibiotic activity. Fluoroquinolones are effective against gram positive cocci (streptococcus pneumonia), gram positive rods (Bacillus anthracis) and gram negative rods (Enterobacter species, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Legionella, Proteus, Pseudomonas aeruginosa, chlamydia, Mycoplasma, serratia and shigella species. Accessed Oct. 24, 2019. Skin prick testing is usually not painful. How long does it take for a boil to heal while taking Bactrim? Drug allergies. gentamicin) and glycopeptides (e.g. At the end of this process, most patients can be safely treated with penicillin and dosed normally. Prometrium is a proprietary brand of progesterone capsule used after menopause in combination with estrogen. Can you take hydroxyzine for anxiety and sleep? A penicillin allergy is one of the most commonly reported drug allergies. Many people experience constipation with narcotic medications. Are you among the 10% of the population who report having a penicillin allergy? Penicillin allergy is the most common drug allergy and is reported in up to 15 percent of hospitalized patients [].A frequent clinical question is whether these patients can safely receive the structurally related cephalosporins or carbapenems (monobactams [ie, aztreonam] are not cross-reactive with penicillins and can be safely given to penicillin-allergic patients). Your allergist / immunologist can review your history and perform skin testing to help you understand if you are still allergic to amoxicillin. Therefore, even with a true allergy to penicillin, there is an excellent chance you could tolerate cephalosporins. Both drug are used to treat bacterial infections such as urinary tract infections, bronchitis and other lung infections. Is It Safe to Take a Fish Oil Capsule With Milk? Lack of protein synthesis means the whole control system of bacterial cell will shut down, resulting in inhibited bacterial growth. Although the cephalosporins are close relatives of penicillins and share a structure called the beta-lactam ring, the risk of a cross-reactivity reaction between penicillins and cephalosporins remains <5%. Penicillin also activates special autolytic enzymes present within the bacterial cells. Merck Manual Professional Version. It may be that sulfa antibiotic allergies are associated with a greater risk of drug allergies overall. Sulfacetamide (BLEPH-10), drops for eye infections. Testing should only be conducted by an allergist trained to recognize and treat potential allergic reactions. All protein synthesis inhibitors bind to 50S ribosomal unit, except for tetracyclines which bind to 30S unit, and inhibit the coupling of m-RNA and t-RNA. Review our cookies information for more details. The process is simple. 5. If the skin testing remains negative, then it is possible you will be given an oral dose of penicillin or amoxicillin. David Wolfe: 10 Natural Antibiotics That Fight Infection. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. There is also a much higher (35 percent) risk of developing an intestinal infection called Clostridium difficile (C. diff). Sulfonamides and trimethoprim are antimetabolites selectively toxic to microorganisms because they interfere with folic acid synthesis. Penicillins are further divided into following groups: Despite the fewer chances of side effects, 10 percent people do suffer from penicillin allergy. A drug rash usually starts within two weeks of taking a new medication and begins as discrete red spots that spread, covering large areas of the body. Has anyone had an anaphylactic reaction to the J&J Covid vaccine? Drug allergies can be hard to diagnose. There are a number of cephalosporin medications available, including cephalexin (brand name: Keflex), cefaclor (brand name: Ceclor), cefuroxime (brand name: Ceftin), cefadroxil (brand name: Duricef), cefprozil (brand name: Cefzil), ceftibuten (brand name: Cedax), cefdinir (brand name: Omnicef), cefpodoxime, and cefixime (brand name: Suprax). What is the Best Way to Clean a BBQ Grill? Some patients who experience a reaction after their first intake of penicillin do not go on to develop a lifelong allergy to it, even if that reaction were as drastic as anaphylaxis. There are also many broad-spectrum antibiotics that can be used in place of penicillin. Tingling or itching in your mouth. Sulfa can be found in many different drugs, but sulfonamide antibiotics cause the majority of sulfa allergies. It is also good practice to keep a list of medications and their doses in a wallet and update all healthcare providers when there are any changes. An allergist / immunologist can perform this testing, and if it is negative, there is a very high chance that the allergy is no longer present. Beta lactamase producing bacteria cane be killed by adding inhibitors of beta lactamases like clavulanic acid, sulbactam and tazobactam to penicillin antibiotics. It's not an antibiotic, but it should also be avoided in people allergic to sulfonamide antibiotics. Home | About | Contact | Copyright | Privacy | Cookie Policy | Terms & Conditions | Sitemap. Can I take clindamycin if I am allergic to penicillin? Two trial participants suffered severe allergic reactions shortly after getting Johnson & Johnsons Covid-19 vaccine, a J&J scientist told an FDA panel on Friday. information highlighted below and resubmit the form. This article deals with alternative antibiotics to penicillin in case of penicillin allergy. https://www.uptodate.com/contents/search. However, most drug reactions are not allergic reactions and do not involve the immune system. Treatment for the current allergy symptoms. Can you take Tylenol if you are allergic to penicillin? Siyanda | Business Directory 198 West 21th Street, Suite 521 New York NY 10010 Phone: (212) 555-7999, Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh euismod tincidunt ut laoreet dolore magna aliquam erat volutpat. Amoxicillin is in the same family of antibiotics as penicillin. The Best Websites to Buy Cheap Business Cards Online, How to Adopt your Stepchild when the Father is Absent. Everyones body chemistry is different and the allergic reaction to penicillin will vary from person to person. Common side effects of Augmentin include: 2023 Caniry - All Rights Reserved Penicillin vk is in the drug class natural penicillins . other information we have about you. Click here to listen to the podcast. Symptoms can begin within moments of ingesting a medication or up to several hours later. What should I avoid while taking ciprofloxacin? Since the 1940s, penicillin has been a go-to drug. It has been reported that a significant percentage of patients labelled as 'penicillin allergic' are not truly allergic to the drug. A total of 36 drugs are known to interact with Penicillin VK . Prometrium is also prescribed to people whose periods stop before menopause. Will Windshield Replacement Raise My Insurance. No interactions were found between penicillin / procaine penicillin and Tylenol. There is a plausible causal relationship between J&J/Janssen COVID-19 Vaccine and a rare and serious adverse eventblood clots with low platelets (thrombosis with thrombocytopenia syndrome, or TTS). How does Augmentin work? Accessed Oct. 22, 2019. Today, the family of penicillin drugs includes more than 15 different antibiotics, such as: These antibiotics can be given by mouth or injection to treat many types of bacterial infections. Corticosteroids. Norepinephrine vs epinephrine: what's the difference? Allergy to penicillins is not a contraindication to the Pfizer/BioNTech, AstraZeneca, Moderna or Janssen COVID-19 vaccine. You may also want to wear a penicillin allergy alert bracelet. Kufel WD, et al. Amoxicillin and penicillin are two of many antibiotics on the market today. Examples of a medication allergy may include anaphylaxis from an antibiotic, angioedema (swelling in layers of the skin) from an ACE inhibitor or a rash from aspirin. This in turn inhibits the transpeptidation or cross linking reaction between peptidoglycans (the structural component of bacterial cell wall) that is necessary in the synthesis of cell wall. These cases are called severe hypersensitivity syndromes. feeling congested. 7. Accessed Oct. 24, 2019. It is also used as hormonal treatment for trans men as part of the transitioning process from female to male. Accessed Oct. 22, 2019. But how it is possible? https://www.merckmanuals.com/professional/immunology-allergic-disorders/allergic,-autoimmune,-and-other-hypersensitivity-disorders/anaphylaxis?query=anaphylaxis. But, now the resistant strains of bacteria are emerging that show resistance to penicillin. If you have a penicillin allergy, the simplest prevention is to avoid the drug. Penicillin Allergy what do you need to know? If we combine this information with your protected information and will only use or disclose that information as set forth in our notice of Over 95 percent of people with penicillin allergy can safely take cephalosporins, which are a bit structurally different from penicillins. Peanut Oil vs. Canola Oil: Which Is More Nutritious? The next time you take the drug, these specific antibodies flag it and direct immune system attacks on the substance. Some nonsteroidal anti-inflammatory drugs, such as celecoxib (Celebrex) The migraine medication sumatriptan (Imitrex) Certain "water pills" (diuretics), such as furosemide (Lasix) and hydrochlorothiazide . The clavulanic acid ingredient makes Augmentin effective against bacteria that amoxicillin or other penicillin drugs may not work against when theyre taken by themselves. The short answer is yes, but you may never have been allergic to begin with. It will be important to let your doctor know what medication you were taking when you had a reaction and what the symptoms were. 1. Can You Outgrow a Penicillin Allergy? Patients who have had an anaphylactic reaction to penicillin are often prescribed an emergency self-injecting epinephrine. What do they prescribe if you are allergic to penicillin? Centers for Disease Control and Prevention, https://www.cdc.gov/antibiotic-use/clinicians/Penicillin-Allergy.html, https://www.ncbi.nlm.nih.gov/books/NBK482250/, https://www.aaaai.org/Tools-for-the-Public/Conditions-Library/Allergies/Penicillin-Allergy-FAQ. Increased exposure to penicillin, because of high doses, repetitive use or prolonged use; Certain illnesses commonly associated with allergic drug reactions, such as infection with HIV or the Epstein-Barr virus; Prevention. Fish oil does not contain protein from shellfish flesh, which typically triggers the shellfish allergic reaction. Peanut oil is present in Sustanon, so you should avoid this medicine if you have an allergy to peanuts. 3. If your doctor determines that you have a penicillin allergy or likely allergy discontinuing the drug is the first step in treatment. However, on repeated exposure there is production of more and more antibodies that tend to stimulate the release of allergy mediators. Sometimes penicillin is the best drug to treat a certain infection. information is beneficial, we may combine your email and website usage information with Pediatric patients Patients may experience one or a variety of symptoms. Albuterol Sulfate belongs to a class of drugs called bronchodilators. Here are some alternative groups of antibiotics for penicillin: Penicillins are beta lactam drugs but in case of allergy to penicillins, other beta lactam drugs can be used safely. However, if youve been told you have a penicillin allergy by a doctor who is not an allergist, you may want to confirm the diagnosis. Yes you can. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. By continuing to browse this site, you are agreeing to our use of cookies. Available for Android and iOS devices. Penicillin allergy occurs when your immune system becomes hypersensitive to the drug mistakenly reacting to the drug as a harmful substance, as if it were a viral or bacterial infection. Sustanon is typically injected once every three weeks at a 1 ml. In addition to drug side effects, drug toxicity can occur when too much of a drug is in a persons body (can be unintentional or intentional). Sulfacetamide (BLEPH-10), drops for eye infections. If the diagnosis is confirmed, ask the allergist to do the following: Penicillin is the most common drug allergy and true penicillin allergy is serious it kills 400 people a year. dosage. Sulfadiazine silver (Silvadene), a cream to prevent and treat burn infections. Mayo Clinic is a not-for-profit organization. Although the mechanisms of the drugs vary, generally they fight infections by attacking the walls of bacterial cells. The best way of dealing with a penicillin allergy is to stay away from all drugs that contain the substance and other closely related substances. Accessed Oct. 22, 2019. Even if your penicillin allergy is confirmed, you can still discuss alternative options if the need for antibiotics arises. Merck Manual Professional Version. There is no predictable pattern to inheritance of penicillin allergy. However, the majority of patients (greater than 90%) may not truly be allergic. Some evidence suggests that trace amounts of it in the food supply may be sufficient for a person's immune system to create an antibody to it. It is also used as hormonal treatment for trans men as part of the transitioning process from female to male. 1. Last updated on July 5, 2021. (March 24, 2019). If you have a history of immediate onset anaphylaxis to multiple classes of drugs or unexplained anaphylaxis please also refer to the additional information at the end of these FAQs. Cephalosporins. No interactions were found between ibuprofen and Penicillin VK. Home | About | Contact | Copyright | Privacy | Cookie Policy | Terms & Conditions | Sitemap. Read more: Could I be allergic to water? Its also worth noting that only 20 per cent of people who think they are allergic to penicillin, actually are. Proteins act as the main control system of bacteria cells. Penicillin vk is used to treat the following conditions: Bacterial Infection. Depending on the type of penicillin, common side effects may include mild nausea or diarrhea, headache, or vaginal itching. Salicylate Allergy Symptoms. 10. Headaches. Evaluation and management of penicillin allergy. For instance, you may be allergic to amoxicillin and oxacillin but not to penicillin G. Certain factors can increase the likelihood of developing an allergy to penicillin such as heredity, other allergies such as food or pollen allergy, other drug allergy and aggressive illnesses that combat the effects of penicillin such as HIV. The typical process of desensitization has excellent success for patients who have experienced immediate reactions to penicillin and involves introduction of very tiny doses of the penicillin drug either orally or intravenously every 15-20 minutes over a period of 4 hours or so. Allergy to penicillin and alternative antibiotics, See numbered references within the article, Difficulty in breathing and chest tightness, Cold clammy skin or blue discoloration of skin. Enfermedades de Inmunodeficiencia Primaria, AAAAI Diversity Equity and Inclusion Statement. Amoxicillin rash: When should I be concerned? This antibiotic treats only bacterial infections. Medlicker features detailed evidence based articles on health, nutrition, pharmaceuticals, fitness and beauty. What will happen during my visit with the allergist / immunologist? Some allergic reactions to drugs - particularly rashes, hives and asthma - can resemble certain diseases. This ultimately ends up in initiation of allergic reactions (1). No, you should not take amoxicillin if you are allergic to penicillin. Medications that most often cause a reaction include: Penicillin, an antibiotic, is the most common cause of drug-induced anaphylaxis. It is generally recommended that you avoid all drugs in the immediate penicillin family (amoxicillin, ampicillin, amoxicillin-clavulanate, dicloxacillin, nafcillin, piperacillin-tazobactam as well as certain drugs in the cephalosporin class (a closely related class to penicillins). This medicine is available only with your doctor's prescription. Under federal rules, the industry tests raw milk, both conventional and organic, for a common class of antibiotics called beta-lactams. Prednisone vs Prednisolone - What's the difference? Tightening of the airways and throat, causing trouble breathing, A history of other allergies, such as food allergy or hay fever, Increased exposure to penicillin, because of high doses, repetitive use or prolonged use, Certain illnesses commonly associated with allergic drug reactions, such as infection with. Review/update the Since the discovery and development of penicillin G, the first type of penicillin, several other types have been developed, including penicillin V, procaine penicillin and benzathine penicillin. gentamicin) and glycopeptides (e.g. 2. Sign up for our daily mail and get the best evidence based health, nutrition and beauty articles on the web.